Overall Description

Article Data information:
- Descriptive information about exomic analysis of 11 patients with with Pyoderma Grangrenosum.

Table S1:

Table S1: Distribution of variants from Exome of 11 patients with with Pyoderma Grangrenosum.

ID group All ExonVar FuncVar ImpactVar Rare
HSM110 VERYSEVERE 103977 31116 290 3858 3389
HSM115 SEVERE 112575 32426 298 3880 3710
HSM117 VERYSEVERE 121600 33352 286 3981 4091
HSM144 SEVERE 107561 32310 298 4017 3721
HSM43 SEVERE 119230 33314 300 4002 3736
HSM48 VERYSEVERE 123682 33079 315 3963 4243
HSM51 SEVERE 110628 32149 296 3903 3610
HSM73 VERYSEVERE 115748 32900 287 3971 4133
HSM83 VERYSEVERE 111706 32003 298 3911 3563
HSM96 SEVERE 112341 31915 278 3896 3455
HSM97 VERYSEVERE 113822 32418 296 3981 3817

FunctVar: Functional variant;
ImpactVar: Variants with a prediction impact higher than 1 or CADD >=15.

Table S2:

Table S2: Distribution of variants from Exome in 11 patients with Pyoderma Grangrenosum, according to severity.

All ExonVar FuncVar ImpactVar Rare
verysevere 114785 32659 293 3967 3954
severe 112341 32310 298 3903 3710

Figure S1

Figure S1: Distribution of variant location from Exome Report in 11 patients with Pyoderma Grangrenosum.

Figure S2

Figure S2: Distribution of variant location in 11 patients with Pyoderma Grangrenosum according to severity.

Figure S3

Figure S3: Distribution of variant function from Exome Report in 11 patients with Pyoderma Grangrenosum.

Figure S4

Figure S4: Distribution of variant function oin 11 patients with Pyoderma Grangrenosum according to severity.

Table S5:

Then, we considered the genes in which variants were present

Table S5: Distribution of genes carrying variants of 11 patients with Pyoderma Grangrenosum.

All ExonVar FuncVar ImpactVar Rare
HSM43 17187 12250 250 2789 2395
HSM48 17285 12234 270 2784 2578
HSM51 16835 12029 251 2750 2357
HSM73 17023 12148 240 2806 2606
HSM83 16876 12009 244 2756 2207
HSM97 16998 12134 237 2767 2414
HSM115 17045 12199 252 2753 2392
HSM117 17185 12230 245 2797 2494
HSM144 16919 12122 248 2800 2347
HSM96 16898 11989 241 2755 2303
HSM110 16639 11847 237 2723 2198

Table S6:

Table S6: Distribution of genes carrying variants of in 11 patients with Pyoderma Grangrenosum according to severity.

All ExonVar FuncVar ImpactVar Rare
verysevere 17010 12141 242 2776 2454
severe 16919 12122 250 2755 2357

Table S7.1:

Table S7.1: List of 20 genes carrying at least one FunctVar in verysevere group

Table S7.2:

Table S7.2: List of 32 genes carrying at least one FunctVar in severe group

Table S8.1:

Table S8.1: List of 241 genes carrying at least one ImpactVar in verysevere group

Table S8.2:

Table S8.2: List of 320 genes carrying at least one ImpactVar in severe group