Supplementary data of the Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease work.

This append is divided into two main sections: supplementary data 1 and supplementary data 2.

Supplementary data 1

This section contains the overall description of exome analysis, the group comparison and the variant enrichment analysis.

- Overall Analysis

The overall analysis includes 10 tables and four figures. These data are a descriptive analysis of whole exome sequencing.

Table S1 Distribution of variants from Exome of 11 Patients diagnosed with Pyoderma gangrenosum.

Table S2 Distribution of variants from Exome of Severity of Pyoderma gangrenosum.

Table S5 Distribution of genes carrying variants of 11 patients with Pyoderma gangrenosum.

Table S6 Distribution of genes carrying variants of Severity of Pyoderma gangrenosum.

Table S7.1 List of 20 genes carrying at least one FunctVar in Very severe group

Table S7.2 list of 32 genes carrying at least one FunctVar in Severe group

Table S8.1 List of 241 genes carrying at least one ImpactVar in Very severe group of PG

Table S8.2 List of 320 genes carrying at least one ImpactVar in severe group of PG

Figure S1 Distribution of variant location from Exome Report in 11 Pyoderma gangrenosum.

Figure S2 Distribution of variant location according to Severity of Pyoderma gangrenosum.

Figure S3 Distribution of variant function from Exome Report in 11 Pyoderma gangrenosum.

Figure S4 Distribution of variant function according to Severity of Pyoderma gangrenosum.

- Group comparison

The Group comparison analysis includes six tables and two figures. These data are a descriptive analysis of whole exome sequencing, comparig each one of studied group

Table S3.1 List of the 23 common FunctVar present on verysevere patient’s group not common on severe group.

Table S3.2 List of the 33 common FunctVar present on severe patient’s group not common on very severe group.

Table S4.1 List of the 23 common ImpactVar present on verysevere patient’s group not common on severe groups

Table S4.2 List of the 33 common ImpactVar present on severe patient’s group not common on very severe groups

Figure S5 Venn diagram of common FunctVar

Figure S6 Venn diagram of common ImpactVar

- Variant enrichment analysis

The Variant enrichment analysis includes three tables and one figure. These data are from common Enriched pathway in each group.

Table S10.1 List of 8 common Enriched Pathways in INTERSECT Group

Table S10.2 List of 14 common Enriched Pathways in VERY SEVERE Group

Table S10.3 List of 9 common Enriched Pathways in SEVERE Group

Figure S7 Venn diagram of common filtered (Features) Enriched Pathways per each group

Supplementary data 2

This section contains the VEA of each group and each individual included in the study.

- Group VEA

Table S9.1 List of 22 Enriched Pathways in very severe group

Table S9.2 List of 17 Enriched Pathways in SEVERE

- Individual VEA

Box 1 List of individual VEA and counts